News Releases

2012

Castle Biosciences licenses thymoma test technology Q1 of 2012

Castle Biosciences Inc. announces acquisition of a worldwide exclusive license from Indiana University Research and Technology Corporation for a gene expression profiling test for use in thymoma.

News Releases

2011

Castle Biosciences licenses use of gene to detect metastasis 10-21-11

Castle Biosciences Inc. is pleased to announce a worldwide exclusive license from Washington University in St. Louis for the use of BAP1 to detect metastasis in patients with melanoma.

News Releases

2009

DecisionDx-GBM biomarker test for brain cancer now available 04-14-09

Castle Biosciences announces availabilty of DecisonDx-GBM biomarker test for brain cancer (glioblastoma multiforme) patients that predicts overall survival to first-line standard of care treatment

News Releases

2008

Brain Cancer Test Option Agreement Announcement 10-07-08

Castle Biosciences signs option agreement for brain cancer (GBM) test with The University of Texas M. D. Anderson Cancer Center

Maetzold Appointed President and CEO 09-26-08

Derek Maetzold Appointed President and CEO, Castle Biosciences Inc

Publications

related to DecisionDx-UM

Onken, et al. 2010.

An Accurate, Clinically Feasible Multi-Gene Expression Assay for Predicting Metastasis in Uveal Melanoma. Jrnl Mol Diagn, 12(4): 461-8.

Worley, et al. 2007.

Transcriptomic versus Chromosomal Prognostic Markers and Clinical Outcome in Uveal Melanoma Clin Cancer Res, 13(5): 1466-71.

Onken, et al. 2006.

Prognostic testing in uveal melanoma by transcriptomic profiling of fine needle biopsy specimens. Jrnl Mol Diagn; 8: 567-73.

Onken, et al. 2004.

Gene expression profiling in uveal melanoma reveals two molecular classes and predicts metastatic death. Cancer Res, 64: 7205-9.


AJCC Cancer Staging Manual, Version 7. 2010. Malignant Melanoma of the Uvea. 547-53.

Harbour. 2010. Molecular Prognostic Testing and Individualized Patient Care in Uveal Melanoma. Am J Ophthalmol, 148: 823–829.

Ainbinder, et al. 2009. The 7th edition AJCC staging system for eye cancer: an international language for ophthalmic oncology. Arch Pathol Lab Med, 133: 1197-8.

Harbour. 2011. Molecular research in uveal melanoma: ushering in a new standard of care. Retina Times, 29: 36-7.

Publications

related to DecisionDx-LGG

Noushmehr, et al. 2010. Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma. Cancer Cell, 17: 1–13.

Van den Bent. 2010. Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician's perspective. Acta Neuropathol, 120: 297–304.

Brat, et al. 2008. Diagnosis of Malignant Glioma: Role of Neuropathology. J Neurooncol, 89: 287-311.

Bruner, et al. 1997. Diagnostic Discrepancies and Their Clinical Impact in a Neuropathology Referral Practice. Cancer, 79(4): 796-803.

Coons, et al. 1997. Improving Diagnostic Accuracy and Interobserver Concordance in the Classification and Grading of Primary Gliomas. Cancer, 79(7): 1381-1393.

Aldape et al. 2000. Discrepancies in diagnoses of neuroepithelial neoplasms: the San Francisco Bay Area Adult Glioma Study. Cancer, 88: 2342–2349.

Publications

related to DecisionDx-GBM

Colman, et al. 2010.

A multigene predictor of outcome in glioblastoma. Neuro Oncol, 12 (1): 49-57.


Phillips, H, et al. 2006. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell, 9:157–173.

Van den Bent. 2010. Interobserver variation of the histopathological diagnosis in clinical trials on glioma: a clinician's perspective. Acta Neuropathol, 2010: 120:297–304.

Brat, et al. 2008. Diagnosis of Malignant Glioma: Role of Neuropathology. J Neuro Oncol, 89: 287-311.

Freije, W, et al. 2004. Gene expression profiling of gliomas strongly predicts survival. Cancer Res, 64: 6503–6510.

Nigro J, et al. 2005. Integrated array-comparative genomic hybridization and expression array profiles identify clinically relevant molecular subtypes of glioblastoma. Cancer Res, 65: 1678–1686.

Nutt, C, et al. 2003. Gene expression-based classification of malignant gliomas correlates better with survival than histological classification. Cancer Res, 63: 1602–1607.

Sun, L, et al. 2006. Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain. Cancer Cell, 9: 287–300.

The Cancer Genome Atlas Research Network. 2008. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature, 455: 1061–1068.

Colman, et al. 2006. Meta-analysis of gene expression profiling data from glioblastoma tumor samples identifies a robust Multigene classifier predictive of survival. Proc Amer Assoc Cancer Res, Volume 47, Abstract # 5688.

Colman, et al. 2007. A robust Multigene classifier predictive of survival in patients with newly diagnosed glioblastoma. Proc Amer Assoc Cancer Res. Vol , Abstract #2700.

Aldape, et al. 2006. Meta-analysis of gene expression profiling data from glioblastoma tumor samples identifies a robust multigene classifier predictive of survival. Journal of the Society for Neuro-Oncology. Abstract GE-01.

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