Caregiver becomes the patient

A 33-year-old caregiver brings her mother to Dr. Khara for treatment of intramucosal cancer. During the visit, she shares that she had been diagnosed with Barrett’s esophagus (BE) in the past. Dr. Khara urges her not to delay her own care and invites her to return for her own surveillance evaluation.

See the case details below to learn how Dr. Khara helped this patient.

Clinical risk factors

A 33-year-old, white, female patient previously diagnosed with long-segment non-dysplastic Barrett’s esophagus (NDBE) sought follow-up evaluation of her condition. Given her mother’s history of esophageal cancer, the patient was motivated to pursue continued surveillance.

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RELEVANT MEDICAL HISTORY

Family history of BE with intramucosal cancer (mother underwent endoscopic eradication therapy (EET))
Class 3 obesity
Smoker
Chronic GERD, on PPIs
History of long-segment NDBE

ADDITIONAL CONSIDERATIONS

None

Endoscopic findings

The endoscopy confirmed the presence of long-segment, NDBE by traditional pathology.

Lower esophagus:

Barrett’s segment length: C2M6
No evidence of nodularity
Pathology returned NDBE
WATS^3Dreturned indefinite for dysplasia

Traditional Management:

Treatment recommendation: 6-month surveillance and PPI use

TissueCypher results

The patient’s TissueCypher results showed a high-risk classification with a 5-year probability of progression of 43%. Having accompanied her mother through esophageal cancer treatment, the patient expressed appreciation that her own disease was identified early, and Dr. Khara recommended EET to prevent likely progression.

Risk class: High
Risk score: 8.9‍
5-year probability of progression: 43%

TissueCypher-guided management

Escalated to EET

"To me, this is a lifesaver because she did not have to go through the morbidity of developing cancer or undergoing cancer treatment. We were able to treat her before she developed a high-risk disease state.”

Harshit Khara, MD

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Case details

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Caregiver becomes the patient

Clinical risk factors

Endoscopic findings

TissueCypher results

"To me, this is a lifesaver because she did not have to go through the morbidity of developing cancer or undergoing cancer treatment. We were able to treat her before she developed a high-risk disease state.”