A health-conscious, 31-year-old male patient sought evaluation for long-standing GERD. He was initially diagnosed with long-segment non-dysplastic Barrett’s esophagus (NDBE), which resulted in significant anxiety. Seeking clarity and potential treatment options, he was referred to Dr. Muthusamy, where repeat evaluation confirmed NDBE and a hiatal hernia. TissueCypher was used to better assess his personalized risk of progression, and the resulting low-risk score provided reassurance to both the patient and physician.

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Case details

No relevant family history
Chronic GERD, PPI use
No obesity
Non-smoker

None

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DecisionDx-SCC Case Studies

A health-conscious, 31-year-old male patient sought evaluation for long-standing GERD. He was initially diagnosed with long-segment non-dysplastic Barrett’s esophagus (NDBE), which resulted in significant anxiety. Seeking clarity and potential treatment options, he was referred to Dr. Muthusamy, where repeat evaluation confirmed NDBE and a hiatal hernia. TissueCypher was used to better assess his personalized risk of progression, and the resulting low-risk score provided reassurance to both the patient and physician.

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Case details

No relevant family history
Chronic GERD, PPI use
No obesity
Non-smoker

None

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DecisionDx-Melanoma Case Studies

A health-conscious, 31-year-old male patient sought evaluation for long-standing GERD. He was initially diagnosed with long-segment non-dysplastic Barrett’s esophagus (NDBE), which resulted in significant anxiety. Seeking clarity and potential treatment options, he was referred to Dr. Muthusamy, where repeat evaluation confirmed NDBE and a hiatal hernia. TissueCypher was used to better assess his personalized risk of progression, and the resulting low-risk score provided reassurance to both the patient and physician.

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Case details

No relevant family history
Chronic GERD, PPI use
No obesity
Non-smoker

None

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MyPath Melanoma Case Studies

Reassuring an anxious patient

A health-conscious, 31-year-old male patient sought evaluation for long-standing GERD. He was initially diagnosed with long-segment non-dysplastic Barrett’s esophagus (NDBE), which resulted in significant anxiety. Seeking clarity and potential treatment options, he was referred to Dr. Muthusamy, where repeat evaluation confirmed NDBE and a hiatal hernia. TissueCypher was used to better assess his personalized risk of progression, and the resulting low-risk score provided reassurance to both the patient and physician.

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Man in a brown suit next to clinical risk factors list for a 31-year-old white male with GERD history.

Clinical risk factors

A 31-year-old, white male reported anxiety about his Barrett’s diagnosis after his index endoscopy.

RELEVANT MEDICAL HISTORY

No relevant family history
Chronic GERD, PPI use
No obesity
Non-smoker

ADDITIONAL CONSIDERATIONS

None

Endoscopic findings

The endoscopy confirmed the presence of long-segment NDBE and a hiatal hernia.

Lower esophagus:

Barrett’s segment length: C4M5
4 cm hiatal hernia
Pathology returned NDBE
WATS^3D returned NDBE

‍Traditional Management:

Treatment recommendation: 3-year surveillance

TissueCypher results

The patient was reassured after receiving a low-risk TissueCypher score and then agreed to a 3-year surveillance interval.

Risk class: Low
Risk score: 2.2
5-year probability of progression: 0.9%

TissueCypher-guided management

Maintain 3-year surveillance

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Graph showing 5-year risk of progression rising exponentially from low to high risk by risk score.

"This specific information related to him, as opposed to providing him with some sort of broad population level data, was what he really needed to become reassured with this approach."

Raman Muthusamy, MD

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