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Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: Executive Summary of an American Society for Radiation Oncology Clinical Practice Guideline

December 9, 2019
This guideline reviews the evidence for the use of definitive and postoperative radiation therapy (RT) in patients with basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC).
DecisionDx-SCC
Cutaneous Squamous Cell Carcinoma
Author: Anna Likhacheva MD, MPH
Publication: Pract Radiat Oncol
Clinical Utility
Prognostic
Dermatology
Publication
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An automated, quantitative multiplex immunofluorescence assay accurately risk stratifies Barrett’s esophagus patients with a community-based diagnosis of low grade dysplasia at a rate comparable to expert pathologists.

October 25, 2019
TissueCypher risk stratified BE patients with a community-based diagnosis of LGD with an accuracy comparable to three renowned expert pathologists.
TissueCypher
Barrett's Esophagus
Author: Nicola F Frei (et al.)
Publication: American Journal of Gastroenterology
Validation
Prognostic
Gastroenterology
Poster
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Evaluation of Additional Spatial and Temporal Information Increases the Overall Accuracy of an Objective Risk Prediction Assay in Patients with Non-Dysplastic Barrett’s Esophagus.

October 25, 2019
TissueCypher may be a effective solution to aid decision-making on surveillance intervals and therapeutic interventions in the management of NDBE patients.
TissueCypher
Barrett's Esophagus
Author: Nicola F Frei (et al.)
Publication: American Journal of Gastroenterology
Validation
Prognostic
Gastroenterology
Poster
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A Cost-Effectiveness Analysis of an Adenocarcinoma Risk Prediction Multi-Biomarker Assay for Patients with Barrett’s Esophagus

October 25, 2019
The TissueCypher assay would be cost-effective after 5 years and improves patient outcomes by improving effectiveness of surveillance and treatment protocols.
TissueCypher
Barrett's Esophagus
Author: Jing Hao (et al.)
Publication: ClinicoEconomics and Outcomes Research
Review Article
Prognostic
Gastroenterology
Publication
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Impact of Gene Expression Profile Testing on the Management of Squamous Cell Carcinoma by Dermatologists

October 1, 2019
To determine the impact of cSCC-GEP test results on management decisions made by dermatologists for cSCC patients.
DecisionDx-SCC
Cutaneous Squamous Cell Carcinoma
Author: Rebeca Teplitz BA
Publication: JDD
Clinical Utility
Prognostic
Dermatology
Publication
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An automated, quantitative multiplex immunofluorescence assay accurately risk stratifies Barrett’s esophagus patients with a community-based diagnosis of low grade dysplasia at a rate comparable to expert pathologists

October 1, 2019
TissueCypher risk stratified BE patients with a community-based diagnosis of LGD with an accuracy comparable to three renowned expert pathologists.
TissueCypher
Barrett's Esophagus
Author: Nicola F Frei (et al.)
Publication: United European Gastroenterology Journal
Validation
Prognostic
Gastroenterology
Poster
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Appropriate Use Criteria for the Integration of Diagnostic and Prognostic Gene Expression Profile Assays into the Management of Cutaneous Malignant Melanoma: An Expert Panel Consensus-Based Modified Delphi Process Assessment

September 13, 2019
Expert panel of 9 dermatologists developed 29 clinical scenarios creating an evidence based framework for AUC recommendations for integration of melanoma GEP tests into clincial practice
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Brian Berman
Publication: SKIN: Journal of Cutaneous Melanoma
Guidelines
Prognostic
Dermatology
Publication
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Level of Evidence Review for a Gene Expression Profile Test for Cutaneous Melanoma

July 29, 2019
Review the current literature and establish the level of evidence for a cutaneous melanoma 31-GEP test.
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Danielle P Dubin
Publication: American Journal of Clinical Dermatology
Guidelines
Prognostic
Dermatology
Publication
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Establishing an evidence-based decision point for clinical use of the 31-gene expression profile test in cutaneous melanoma

July 8, 2019
Multi center study establishing appropriate use criteria for determining risk of recurrence in patients with tumors >0.3mm in thickness
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Etan Marks
Publication: SKIN: Journal of Cutaneous Melanoma
Validation
Prognostic
Dermatology
Publication
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Independent validation of a tissue systems pathology test to predict progression Barrett’s esophagus patients (PODIUM PRESENTATION AT DDW 2019, SAN DIEGO 1068)

May 1, 2019
TissueCypher identifies NDBE patients who are at increased risk for progression to HGD/EAC and may benefit from increased surveillance or early intervention.
TissueCypher
Barrett's Esophagus
Author: Jon M Davison (et al.)
Publication: Gastroenterology
Validation
Prognostic
Gastroenterology
Presentation
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Prospective validation of the prognostic 31-gene expression profiling test in primary cutaneous melanoma

April 5, 2019
Independent, prospective study with over 3.5 years of follow-up, showing results consistent with previous validation studies with GEP class score as statistically associated with MSS, DMFS and RFS.
DecisionDx-Melanoma
Cutaneous Melanoma
Author: Jennifer Keller
Publication: Cancer Medicine
Validation
Prognostic
Dermatology
Publication
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Correlation of melanoma gene expression score with clinical outcomes on a series of melanocytic lesions

April 1, 2019
Clinical validation study of the 23-GEP in lesions with clinical outcomes and follow-up data
MyPath Melanoma
DiffDx-Melanoma
Cutaneous Melanoma
Author: Jennifer Ko
Publication: Human Pathology
Validation
Diagnostic
Dermatology
Publication
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